Combining real-world data with AI-powered evidence synthesis to accelerate clinical development and market access
London, ON – 30th April 2026 Pulse Infoframe Inc., a global leader in real-world evidence (RWE) generation and patient registries, and Nested Knowledge, a pioneer in AI-powered systematic review and meta-analysis, today announced a strategic partnership to create a seamless, living evidence ecosystem for the life sciences industry.
Industry Challenge
Organizations face increasing pressure to generate integrated evidence across real-world data and published literature. At the same time, they must meet faster regulatory and payer expectations. In addition, they must also navigate fragmented data sources and disconnected literature. At the same time, expectations from regulators, HTA bodies, and payers continue to rise. As a result, this partnership addresses these challenges directly. It combines two industry leading platforms into a connected evidence foundation
What This Partnership Enables
By integrating Pulse Infoframe’s global real-world data platform with Nested Knowledge’s AI-powered literature synthesis capabilities, the partnership delivers:
- A unified view of real-world and published evidence
- Continuous, “living” evidence generation that stays up to date
- Faster identification of evidence gaps
- Better-informed study design and endpoint selection
- Streamlined, submission-ready insights for regulatory and market access
Together, the two organizations support clinical development from early-stage research through post-marketing and commercialization helping organizations find the signal in the noise and accelerate time to market.
Leadership Perspectives
“Nested Knowledge has reduced the time to optimize study design and study landscape intelligence by incorporating a thoughtful scientific approach to systematically reviewing the literature and providing real-time and dynamic insights leveraging the power of their AI enabled technology. The combination of Pulse Infoframe and Nested Knowledge creates a unique and necessary product for biotech and pharma who rely on data to help inform their clinical development pathways. In the absence of informed decision making, we continue to face therapeutic failure and while no approach is perfect, we have an opportunity to mitigate risks and advance care for patients, that is what our combination of companies provides.”
– Dr. Femida Gwadry-Sridhar, Founder & CEO, Pulse Infoframe
“Pulse Infoframe is at the cutting edge of Real-world data (RWD)generation, curation, and utilization to accelerate treatments enabled by the expertise in study designs that support regulatory submissions. Their unique integration of real-world clinical, phenotypic and genomic, rare-disease, and oncology data into a single platform helps generate actionable insights on treatment effectiveness and patient outcomes– exactly what Nested Knowledge focuses on in the evidence synthesis space. Connecting capabilities for evidence generation and evidence synthesis will provide a truly comprehensive platform for data management, analytics and insights.”
– Kevin Kallmes, Founder & CEO, Nested Knowledge
Looking Ahead
Expectations for clinical and regulatory evidence continue to increase. Therefore, integrated approaches will play a larger role in decision making across development. These approaches connect real world data with AI driven literature synthesis. They improve speed, transparency, and efficiency.
Pulse Infoframe and Nested Knowledge will continue advancing this vision. They will do so with industry, academic, and patient advocacy partners. The goal is to enable scalable and efficient evidence generation. This ultimately supports better patient outcomes.
About Pulse Infoframe
Pulse Infoframe is a pioneer and leading provider in the life sciences industry with a real-world evidence (RWE) generation platform enabling the acceleration of scientific research and the development of new therapeutic products. Pulse’s enterprise-grade, adaptive technology is trusted by a global, ‘blue-chip’ customer base of top pharma companies, patient advocacy groups, and academic medical centers. Learn more at www.pulseinfoframe.com
About Nested Knowledge
Nested Knowledge® offers a comprehensive software platform for systematic literature review and meta-analysis. The software is composed of two parts which work in tandem: AutoLit®, which enables users to search, screen, extract data, and complete critical appraisal; and Synthesis, which allows teams to visualize, analyze, publish, and share insights. Learn more at nested-knowledge.com
